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Xanax and Melatonin - Drug Interactions / Side Effects.
Dec 17, 2007 There are no known interactions between these two medications as far as I've seen in my research, but they both can do similar things to your body. I Can I take Melatonin with Xanax XR? There is no known interaction between Melatonin and Xanax XR in our records. However, an interaction may still exist.